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Dujovne et al performed a multicenterrandomizeddouble-blindplacebo-controlled study to evaluate the safety and efficacy of ezetimibe 10 mg in 892 patients with primary hyper-cholesterolemiaThese patients had previously been treated with lipid-lowering agentsbile acid sequestrantsnicotinic acidfibratesand/or statinsEzetimibe 10 mg or placebo was administered daily for a period of 12 weeksThe primary efficacy endpoint was the percentage reduction in direct plasma LDL cholesterol from baselineSecondary endpoints included changes and percentage changes from baseline in LDL cholesterol calculated by the Friedewald equationtotal cholesteroltriglycerideand HDL cholesterol levels over time and at endpointand changes from baseline in HDL cholesterol subfractions HDL 2 cholesterol and HDL 3 propecia europe online. cholesterolapolipoprotein A-Iapolipo-protein Band lipoproteinaat endpoint4

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