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Because of its inhibitory effect on fibroplasiamethylprednisolone may mask the signs of infection and enhance dissemination of the infecting organismHenceall animal patients receiving methylprednisolone should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by use of appropriate antibacterial measuresor administration of methylprednisolone should be discontinued.
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Areas not suitable for injection are those that are anatomically inaccessible such as spinal joints and those like the sacroiliac jointswhich are devoid of synovial spaceTreatment failures are most frequently the result of failure to enter the synovial spaceIf failures occur when injections into the synovial spaces are certainas determined by aspiration of fluidrepeated injections are usually futileLocal therapy does not alter the underlying disease processand whenever possible comprehensive therapy including physiotherapy and orthopedic correction should be employed.
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