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Subjects with moderate n 17 or severe n 14 renal impairment did not tolerate 600 mg or 400 mg daily doses of copegus, respectively, due to copegus-related adverse reactions, mainly anemia, and exhibited 20 to 30 higher ribavirin plasma exposures despite frequent dose modifications compared to subjects with normal renal function creatinine clearance greater than 80 ml min receiving the standard dose of copegus.
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