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3XULN with total biliubin >2XULN. outin monitoing LTs duing thapy without liv disas: not commndd. Activ bladd canc: not commndd. Pihistoy bladd canc: consid glycmic contol bnits vs. isk canc cunc. isk actus (sp. mals). Pom gula y xams. sumption pmnopausal ovulation in anovulatoy patints may occu (may sult in unintndd pgnancy). Pgnancy (Cat.C): consid using insulin instad. Nusing moths: not commndd.
Th DA appovd Actos in 1999, Actoplus Mt in 2005 and Actoplus Mt X in 2009.
Clinical studis dmonstat that ACTOS impovs insulin snsitivity in insulin-sistant patints. ACTOS nhancs cllula sponsivnss tinsulin, incass insulin-dpndnt glucos disposal and impovs hpatic snsitivity tinsulin. In patints with typ 2 diabts, th dcasd insulin sistanc poducd by ACTOS sults in low plasma glucos concntations, low plasma insulin concntations, and low HbA1c valus. In contolld clinical tials, ACTOS had an additiv ct on glycmic contol whn usd in combination with a sulonylua, mtomin, insulin [s Clinical Studis ].
In th scond tial, 827 patints w andomizd tciv ith 30 mg 45 mg ACTOS onc daily 24 wks in addition tthi cunt mtomin gimn. Th man duction om baslin at Wk 24 in HbA1c was 0.8% th 30 mg dos and 1.0% th 45 mg dos (s Tabl 23). Th man duction om baslin at Wk 24 in PG was 38 mg/dL th 30 cialis 2.5 without prescription. mg dos and 51 mg/dL th 45 mg dos.
Mmb, th conston diabts contol is unchangd: it is impotant tollow a mal plan and tgt plnty physical activity. Diabts pills a anoth tool thlp manag you blood glucos.
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