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Cases of tinnitus and reversible or irreversible hearing impairment and deafness have been reportedReports usually indicate that LASIX ototoxicity is associated with rapid injectionsevere renal impairmentthe use of higher than recommended doseshypoproteinemia or concomitant therapy with aminoglycoside antibioticsethacrynic acidor other ototoxic drugsIf the physician elects to use high dose parenteral therapycontrolled intravenous infusion is advisablefor adultsan infusion rate not exceeding 4 mg LASIX per minute has been usedSee PRECAUTIONSDRUG INTERACTIONS
In cirrhosiselectrolyte and acid/base imbalances may lead to hepatic encephalopathyprior to initiation of therapycorrect electrolyte and acid/base imbalanceswhen hepatic coma is present.
Measure liquid medicine with the dosing syringe providedor with a special dose-measuring spoon or medicine cupIf you do not have a dose-measuring deviceask your pharmacist for one.
Serum electrolytesparticularly potassiumCO2creatinine and BUN should be determined frequently during the first few months of LASIX therapy and periodically thereafterSerum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluidsAbnormalities should be proscar 5 mg. corrected or the drug temporarily withdrawnOther medications may also influence serum electrolytes.
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before taking this medication, tell your doctor if you are taking any of the following medicines an angiotensin-converting-enzyme ace inhibitor such as benazepril lotensin , enalapril vasotec , captopril capoten , lisinopril prinivil, zestril , quinapril accupril , ramipril altace , fosinopril monopril , moexipril univasc , trandolapril mavik , and others; a beta-blocker such as acebutolol sectral , atenolol tenormin , bisoprolol zebeta , carvedilol coreg , labetalol normodyne, trandate , metoprolol lopressor, toprol xl , propranolol inderal , and others; a water pill diuretic such as hydrochlorothiazide hctz, hydrodiuril, others , chlorothiazide diuril , chlorthalidone hygroton, thalitone , furosemide lasix , torsemide demadex , bumetanide bumex , ethacrynic acid edecrin , triamterene dyrenium, maxzide, dyazide , amiloride midamor , spironolactone aldactone , and others; a medicine used to treat myasthenia gravis such as pyridostigmine mestinon or neostigmine prostigmin ; an oral or injectable anticoagulant such as warfarin coumadin , heparin, ardeparin normiflo , dalteparin fragmin , danaparoid orgaran , enoxaparin lovenox , or tinzaparin innohep ; phenytoin dilantin , valproic acid depakene, others , or sodium valproate depakote ; an oral diabetes medicine such as glipizide glucotrol , glyburide micronase, diabeta , and others; methotrexate folex pfs, rheumatrex dose pack, others ; acetazolamide diamox, others ; probenecid benemid ; or sulfinpyrazone anturane .