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Naltrexone is a drug that blocks the effects of drugs called opioids.

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There may be a higher risk of hepatocellular injury with single doses above 50 mgand use of higher doses and extended dosing intervals should balance the possible risks against the probable benefitssee WARNINGS

The safe use of REVIA in pediatric patients younger than 18 years old has not been established.

The mechanism of action of REVIA in alcoholism is not understoodhoweverinvolvement of the endogenous opioid system is suggested by preclinical dataREVIAan opioid receptor antagonistcompetitively binds to such receptors and may block the effects of endogenous opioidsOpioid antagonists have been shown to reduce alcohol consumption by animalsand REVIA has been shown to reduce alcohol consumption in clinical studies.

Clinical studies indicate that 50 mg of REVIA will block the pharmacologic effects of 25 mg of intravenously administered heroin for periods as long as 24 hoursOther data suggest that doubling the dose of REVIA provides blockade for 48 hoursand tripling the dose of REVIA provides blockade for about 72 hours.

There is also the possibility that a patient who is treated with REVIA could overcome the opioid blockade effect of REVIAAlthough REVIA is a potent antagonistthe blockade produced by REVIA is surmountableThe plasma concentration of exogenous opioids attained immediately following their acute administration may be sufficient to overcome the competitive receptor blockadeThis poses a potential risk to individuals who attempton their ownto overcome the blockade by administering large online pharmacy dubai, online pharmacy dubai, online pharmacy dubai, online pharmacy dubai, online pharmacy dubai, online pharmacy dubai. amounts of exogenous opioidsAny attempt by a patient to overcome the antagonism by taking opioids is especially dangerous and may lead to life-threatening opioid intoxication or fatal overdosePatients should be told of the serious consequences of trying to overcome the opioid blockadesee PATIENT INFORMATION

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