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In healthy adultsthe apparent volume of distribution is approximately 20 L/kgindicating extensive tissue distributionMefloquine may accumulate in parasitized erythrocytesExperiments conducted in vitro with human blood using concentrations healthyman. between 50 and 1000 mg/mL showed a relatively constant erythrocyte-to-plasma concentration ratio of about 2 to 1The equilibrium reached in less than 30 minutes was found to be reversibleProtein binding is about 98

The main challenge with preventing malaria is that some species of mosquito in certain countries have become resistant to the commonly used drugs such as chloroqine and proguanilLariam was developed to overcome such resistance and so was deemed to be useful if travelling to countries where there is a type of malaria that is particularly difficult to treatBut no single medicine is effective against all malaria parasitesThe finasteride london. choice of a particular medicine depends on the sensitivity of the malaria parasites found in particular areas.

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if vomiting continues, check with your doctor for a different medication to use in place of lariam.