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There was no significant difference in time to objective tumor progression between treatment groupssee Figure 2Objective tumor progression was defined as the appearance of any bone metastases or the worsening of any existing bone metastases on bone scan attributable to metastatic diseaseor an increase by 25or more of any existing measurable extraskeletal metastasesThe hazard ratio for time to progression of Casodex plus LHRH analog to that of flutamide plus LHRH analog was 0.9395confidence interval0.79 to 1.10
In a periand post-natal development studyfemale rats were dosed from gestation day 16 to lactation day 22 and allowed to litter and rear their offspring to weaningSurvival and weights of offspring during lactation were reduced for litters from maternal rats receiving doses of 250 mg/kg/dayapproximately 2 times the human exposure at the recommended doseMale offspring of rats receiving doses of 10 mg/kg/dayapproximately 0.7 times the human exposure at the recommended doseand abovewere observed to have reduced anogenital distancesmaller secondary sex organscryptorchidism and hypospadias resulting in an inability to mate and impregnate their female partnersFemale offspring of rats receiving doses of 10 mg/kg/dayapproximately geniic paxil overnite shipping. 0.7 times the human exposure at the recommended doseand above had reduced pregnancy rates.
Endocrine system side effects including gynecomastia38and breast pain39have been reported with the use of bicalutamidethe active ingredient contained in Casodexas a single agentSeveral cases of decreases in prostate specific antigenPSAafter withdrawal of bicalutamide therapyreferred to as antiandrogen withdrawal syndromehave been reportedRef]
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