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The summary of product characteristics for florinef 100 microgram tablets reports that because fludrocortisone is a potent mineralocorticoid, dosage and salt intake should be monitored to avoid the development of hypertension, oedema or weight gain and that monitoring of serum electrolytes is advisable during prolonged therapy prolonged therapy not further defined .

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Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation.

The physician should advise the patient to report any medical history of heart diseasehigh blood pressureor kidney or liver disease and to report current use of any medicines to determine if these medicines might interact adversely with fludrocortisone acetatesee Drug Interactions

Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressuresalt and water retentionand increased excretion of potassiumThese effects are less likely to occur with the synthetic derivatives except when used in large dosesHoweversince fludrocortisone acetate is a potent mineralocorticoidboth the dosage and salt intake should be carefully solarteam windesheim. monitored in order to avoid the development of hypertensionedemaor weight gainPeriodic checking of serum electrolyte levels is advisable during prolonged therapydietary salt restriction and potassium supplementation may be necessaryAll corticosteroids increase calcium excretion.

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