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Linezolid’s mechanism of action differs from those of other antibiotic classesIn vitro studies with clinical isolatesincluding methicillin-resistant staphylococcivancomycin-resistant enterococciand penicillinand erythromycin-resistant streptococciindicate that linezolid is usually active against organisms which are resistant to one or more other classes of antimicrobial agents.
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Supportive care is advised together with maintenance of glomerular filtrationApproximately 30of a linezolid dose is removed during 3 hours of haemodialysisbut no data are available for the removal of linezolid by peritoneal dialysis or haemoperfusionThe two primary metabolites of linezolid are also removed to some extent by haemodialysis.
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