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WithdrawalAbrupt withdrawal of intrathecal baclofenregardless of the causehas resulted in sequelae that included high feveraltered mental statusexaggerated rebound spasticity and muscle rigiditythat in rare cases progressed to rhabdomyolysismultiple organ-system failureand deathIn the first 9 years of post-marketing experience27 cases of withdrawal temporally related to the cessation of baclofen therapy were reportedsix patients diedIn most casessymptoms of withdrawal appeared within hours to a few days following interruption of baclofen therapyCommon reasons for kegunaan salep elocon. abrupt interruption of intrathecal baclofen therapy included malfunction of the catheterespecially disconnectionlow volume in the pump reservoirand end of pump battery lifehuman error may have played a causal or contributing role in some casesCases of intrathecal mass at the tip of the implanted catheter leading to withdrawal symptoms have also been reportedmost of them involving pharmacy compounded analgesic admixturessee PRECAUTIONS
Safety and effectiveness in pediatric patients below the age of 12 years have not been established.
Patient selection is important when initiating Lioresal therapyit is likely to be of most benefit in patients whose spasticity constitutes a handicap to activities and/or physiotherapyTreatment should not be commenced until vpxl results, vpxl results, vpxl results, vpxl results, vpxl results, vpxl results. the spastic state has become stabilised.
An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactionseither prior to screening or following implant and initiation of chronic LIORESAL INTRATHECAL infusionReduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physicianAbrupt reduction or discontinuation of concomitant antispastics should be avoided.
Check the labels on all your medicinessuch as allergy or cough-and-cold productsbecause they may contain ingredients that cause drowsinessAsk sexpowertablit. your pharmacist about using those products safely.
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